Language Changes in Late-Onset Alzheimer’s Disease
Alzheimer’ s disease (AD) is the most common cause of cognitive decline and dementia in the elderly. Language disturbances appear early in AD and constitute an important element of the diagnosis, although they are usually overshadowed by impairment of memory and executive functions. It is known that language is impaired disproportionally in AD: the semantic and pragmatic language systems are more impaired than syntax. However, syntactic features can also be impaired in the moderate and severe stages of AD. The features of language can be different depending on the onset of AD. AD is classified into two subtypes: early-onset (before 65 years of age) and late-onset (over 65 years of age). Late-onset is the most common form of AD and the aim of this study is to reveal the language changes of 39 patients with late-onset AD and compare it with an age/education-matched control group that has no neurological and psychological problems. The data was transcribed using transcript symbols following Du Bois. The results revealed that although the number of the sentences were more, the speech amount of late-onset AD patients was smaller than the control group. Late-onset AD patients mostly produced sentences in “Picnic” picture description test and fewer sentences in random speech test. Moreover, the sentence length of LAD patients was bigger in “Cookie theft” picture description test and smaller in “Picnic” picture description test. However, their general performance about the speech amount was poor. The other findings were about the coordinated and compound sentences. It was revealed that late-onset AD patients used similar number of coordinated and compound sentences compared to their aged matched peers. In conclusion, it is clear that the syntactic features of LAD patients is not completely different from the people with normail aging.
Ahmed, S., de Jager, C.A., Haigh, A.M.F., & Garrard, P. (2012). Logopenic aphasia in Alzheimer’s disease: clinical variant or clinical feature? Journal of Neurology, Neurosurgery, and Psychiatry, 83(11), 1056–1062. https://doi.org/10.1136/jnnp-2012-302798
Altmann, L.J., & McClung, J.S. (2008). Effects of semantic impairment on language use in Alzheimer’s disease. In Seminars in speech and language, 29(1), 18–31. https://doi.org/10.1055/s-2008-1061622
Bates, E., Harris, C., Marchman, V., Wulfeck, B., & Kritchevsky, M. (1995). Production of complex syntax in normal ageing and Alzheimer’s disease. Language and Cognitive Processes, 10(5), 487–539. https://doi.org/10.1080/01690969508407113
Bayles, K., Kazniak, A., & Tomoeda, C.K. (1987). Communication and cognition in normal aging and dementia. Boston: Little Brown.
Beber, B.C., Cruz, A.N., & Chaves, M.L. (2015). A behavioral study of the nature of verb production deficits in Alzheimer’s disease. Brain and Language, 149, 128–134. https://doi.org/10.1016/j.bandl.2015.07.010
Boschi, V., Catricala, E., Consonni, M., Chesi, C., Moro, A., & Cappa, S.F. (2017). Connected speech in neurodegenerative language disorders: A review. Frontiers in Psychology, 8(269), 1–21. https://doi.org/10.3389/fpsyg.2017.00269
Budson, A.E. (2011). Memory Dysfunction in Dementia (Vol. 7), The handbook of Alzheimer’s disease and other dementias. In A.E. Budson & N.W. Kowall (Eds.). John Wiley, Sons. https://doi.org/10.1002/9781444344110.ch11
Camicioli, R. (2007). Differentiation from non-Alzheimer dementia. Clinical Diagnosis and Management of Alzheimer’s Disease. Editor Serge Gauthier. UK: Informa.
Can, E., & Kuruoglu, G. (2017). Sentence Length of Turkish Patients with Early and Late-Onset Alzheimer’s Disease. Humanities and Social Sciences Review, 6(02), 69–78.
Can, E., & Kuruoglu, G. (2018). A comparison of Sentence Production of Turkish Patients with Early and Late-Onset Alzheimer’s Disease. International Journal of Psycho-Educational Sciences, 7(1), 74–85.
Can, E., Kuruoglu, G., & Ozsoy, A.S. (2018). Geç başlangıçlı Alzheimer tipi demans hastalarının dil kullanımı: Basit tümce açısından inceleme. In Neslihan Kansu Yetkiner & Mehmet Şahin (Eds.), Dilbilim ve Çevribilim Yazıları, (pp. 36–47). Ankara: Anı Yayıncılık.
Caplan, D., & Waters, G.S. (1999). Verbal working memory and sentence comprehension. Behavioral and Brain Sciences, 22(01), 77–94. https://doi.org/10.1017/S0140525X99001788
Caramelli, P., Mansur, L.L., & Nitrini, R. (1998). Language and communication disorders in dementia of the Alzheimer type. In Harry A. Whitaker & Brigitte Stemme (Eds.), Handbook of Neurolinguistics, (pp. 463–473). USA : Academic Press.
Croisile, B., Ska, B., Brabant, M.J., Duchene, A., Lepage, Y., Aimard, G., & Trillet, M. (1996). Comparative study of oral and written picture description in patients with Alzheimer’s disease. Brain Language, 53, 1–19. https://doi.org/10.1006/brln.1996.0033
Cummings, J.L. (2007). Alzheimer Hastalığı ve İlişkili Demansların Nöropsikiyatrik Özellikleri. Çev. Doç. Dr. Gökhan Erkol ve Dr. Barış Metin. İngiltere: Taylor Francis.
Davidson, T., & Villiers, J.D. (2011). Language Impairment. The Gale Encyclopedia of Children’s Health: Infancy Through Adolescence. In Jacqueline L. Longe (Ed.). Detroit : Gale Cengage Learning.
Du Bois, J.W., Schuetze-Coburn, S., Cumming, S., & Paolino, D. (1993). Outline of discourse transcription. In Jane A. Edwards & Martin D. Lampert (Eds.), Talking Data: Transcription and coding in discourse research, (pp. 45–89). New York: Psychology Press.
Emery, V.O. (2000). Language impairment in dementia of the Alzheimer type: A hierarchical decline? International Journal of Psychiatry in Medicine, 30, 145–164. https://doi.org/10.2190/X09P-N7AU-UCHA-VW08
Ferris, S.H., & Farlow, M. (2013). Language impairment in Alzheimer’s disease and benefits of acetylcholinesterase inhibitors. Clinical interventions in aging, 8, 1007–1014. https://doi.org/10.2147/CIA.S39959
Franz, J.F. (2001). Alzheimer’s Disease. Gale Encyclopedia of Nursing and Allied Health. In Kristine M. Krapp (Ed.). Detroit : Thomson Gale.
Fraser, K.C., Meltzer, J.A., & Rudzicz, F. (2016). Linguistic features identify Alzheimer’s disease in narrative speech. Journal of Alzheimer’s Disease, 49(2), 407–422. https://doi.org/10.3233/JAD-150520
Glosser, G., Friedman, R., Kohn, S., Sands, L., & Grugan, P. (1998). Cognitive mechanisms for processing nonwords: Evidence from Alzheimer’s disease. Brain and Language, 63, 32–49. https://doi.org/10.1006/brln.1997.1924
Gourle, M.M. (2001). Occupational therapy. Gale Encyclopedia of Nursing and Allied Health. In Kristine M. Krapp (Ed.). Detroit: Thomson Gale.
Guha, M. (2012) The Gale Encyclopedia of Children’s Health: Infancy through Adolescence (2nd ed.), Reference Reviews. Vol. 26. Issue: 3, pp. 35–37, https://doi.org/10.1108/09504121211211398
Hier, D.B., Hagenlocker, K., & Shindler, A.G. (1985). Language disintegration in dementia: effects of etiology and severity. Brain Language, 25, 117–133. https://doi.org/10.1016/0093-934X(85)90124-5
Hollingworth, P., & Williams, J. (2011). Genetic Risk Factors for Dementia. In A.E. Budson & N.W. Kowall (Eds.), The handbook of Alzheimer’s disease and other dementias (Vol. 7). John Wiley & Sons. https://doi.org/10.1002/9781444344110.ch6
Ikejima, C., Yasuno, F., Mizukami K., et al. (2009). Prevalence and causes of early-onset dementia in Japan: a population-based study. Stroke, 40, 2709–2727. https://doi.org/10.1161/STROKEAHA.108.542308
Joubert, S., Joncas, S., Barbeau, E., Joannette, Y., & Ska, B. (2007). Cognition. In S. Gauthier (Ed.), Clinical diagnosis and management of Alzheimer’s disease (3rd ed.), (pp. 165-176). Martin Dunitz & Parthenon publishing.
Joubert, S., Gour, N., Guedj, E., Didic, M., Guériot, C., Koric, L., Ranjeva, J., Felician, O., Guye, M., & Ceccaldi, M. (2016). Early-onset and late-onset Alzheimer’s disease are associated with distinct patterns of memory impairment. Cortex, 74, 217–232. https://doi.org/10.1016/j.cortex.2015.10.014.
Kaplan, E., Goodglass, H., & Weintraub, S. (2001). Boston naming test (2nd ed.). Philadelphia, PA: Lippincott Williams & Wilkins.
Kavé, G., & Levy, Y. (2003). Morphology in picture descriptions provided by persons with Alzheimer’s disease. Journal of Speech, Language, and Hearing Research, 46, 341–352. https://doi.org/10.1044/1092-4388(2003/027)
Kavé, G., & Dassa, A. (2018). Severity of Alzheimer’s disease and language features in picture descriptions. Aphasiology, 32(1), 27–40. https://doi.org/10.1080/02687038.2017.1303441
Kemper, S., LaBarge, E., Ferraro, R., Cheung, H., & Storandt, M. (1993). On the preservation of syntax in Alzheimer’s disease. Archives of Neurology, 50, 81–86. https://doi.org/10.1001/archneur.1993.00540010075021
Kemper, S., Thompson, M., & Marquis, J. (2001). Longitudinal change in language production: E’ects of aging and dementia on grammatical complexity and propositional content. Psychology and Aging, 16, 600–614. https://doi.org/10.1037/0882-7922.214.171.1240
Kensinger, E. (1996). Early and Late Onset as Subdivisions of Alzheimer’s Disease. Harvard Brain, (pp. 26–36).
Kertesz, A. (2007). Western Aphasia Battery (Revised) PsychCorp. San Antonio.
Lira, J.O., Ortiz, K.Z., Campanha, A.C., Bertolucci, P.H.F., & Minett, T.S.C. (2011). Microlinguistic aspects of the oral narrative in patients with Alzheimer’s disease. International Psychogeriatrics, 23(3), 404–412. https://doi.org/10.1017/S1041610210001092
Lu, L.C., & Bludau, J.H. (2011). Alzheimer’s Disease (Biographies of Disease). California: Greenwood.
Lukic, S., Bonakdarpour, B., Den Ouden, D., Price, C., & Thompson, C. (2013). Neural Mechanisms of Verb and Sentence Production: A Lesion-deficit Study. Procedia-Social and Behavioral Sciences, 94, 34–35. https://doi.org/10.1016/j.sbspro.2013.09.014
Mamede-Rosa, M.L. (2008). Alzheimer’s Disease. Alzheimer’s Disease Research Trends. In A.P. Chan (Ed.). New York: Nova Science Publishers.
Mandell, A.M., & Green, R.C. (2011). Alzheimer’ s Disease. In A.E. Budson & N.W. Kowall (Eds.), The handbook of Alzheimer’s disease and other dementias (Vol. 7). John Wiley & Sons. https://doi.org/10.1002/9781444344110.ch1
Masrani, V. (2018). Detecting dementia from written and spoken language (T). University of British Columbia. Retrieved from https://open.library.ubc.ca/collections/ubctheses/24/items/1.0362923.
Multani, N., Rudzicz, F., & Tartaglia, M.C. (2016). Comparing Neuropsychiatric and Language Features in Early-onset and Late-onset Alzheimer’s Disease. Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association, 12(7), 490. https://doi.org/10.1016/j.jalz.2016.06.968
Rainville, C., Caza, N., Belleville, S., & Gilbert, B. (2007). Neuropsychological assessment. In S. Gauthier (Ed.), Clinical Diagnosis and Management of Alzheimer’s Disease (3rd.). Oxon : Informa Healthcare.
Reilly, J., Troche, J., & Grossman, M. (2011). Language Processing in Dementia. In A.E. Budson & N.W. Kowall (Eds.), The handbook of Alzheimer’s disease and other dementias (Vol. 7). John Wiley & Sons. https://doi.org/10.1002/9781444344110.ch12
Soukup, J.E. (1996). Alzheimer’s Disease: A Guide to Diagnosis, Treatment, and Management. USA : Praeger Publishers.
Sunderman, M. (2012). The Effects of Alzheimer’s Disease on Expressive Language Over Time. (Unpublished doctoral dissertation). Columbus, OH : Ohio State University.
Sung, J.E., Kyung, K.J., & Hyang, J.J. (2013). Working Memory Capacity and its Relation to Passive Sentence Comprehension in Persons with Mild Cognitive Impairment. In Clinical Aphasiology Conference : Clinical Aphasiology Conference.
Swain, L. (2001). Aging and the aged. Gale Encyclopedia of Nursing and Allied Health. Editors Kristine M. Krapp. Detroit : Thomson Gale.
Swartout-Corbei, D.M. (2001). Dementia. Gale Encyclopedia of Nursing and Allied Health. Editors Kristine M. Krapp. Detroit : Thomson Gale.
Thomas, P., & Hazif-Thomas, C. (2016). Language Disorders in Alzheimer’s Disease and Phatic Function. Open Journal of Psychiatry, 6, 213–217. http://dx.doi.org/10.4236/ojpsych.2016.63026
Waters, G.S., & Caplan, D. (1997). Working memory and on-line sentence comprehension in patients with Alzheimer’s disease. Journal of Psycholinguistic Research, 26(4), 377–400. https://doi.org/10.1023/A:1025073902269
Waters, G.S., & Caplan, D. (1999). Verbal working memory capacity and on-line sentence processing efficiency in the elderly. In S. Kemper & R. Kliegl (Eds.), Constraints on language: Aging, grammar and memory, (pp. 107–136). Boston, MA: Kluwer.
Waters, G.S., & Caplan, D. (2001). Age, working memory and on-line syntactic processing in sentence comprehension. Psychology and Aging, 16, 128–144. https://doi.org/10.1037/0882-79126.96.36.199
Zhu, X.C, Tan, L, Wang, H.F. et al. (2015). Rate of early onset Alzheimer’s disease: a systematic review and meta-analysis. Ann. Transl. Med, 3, 38 –43.
Zimmerer, V.C., Wibrow, M., & Varley, R.A. (2016). Formulaic language in people with probable Alzheimer’s disease: a frequency-based approach. Journal of Alzheimer’s Disease, 53(3), 1145–1160. https://doi.org/10.3233/JAD-160099
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